For our client, a leading international pharmaceutical company with headquarters in Basel, we are looking or a motivated personality in the function of
Working principally on small molecule projects, our client is looking for a motivated candidate to fill the gaps in the ADME field for drug development. You will work on advancing in vitro assay techniques to estimate fractions metabolized by enzymes to support clinical PK prediction and drug-drug interaction (DDI) risk assessment for small molecules portfolios.
- Conduct the laboratory work in enzymology/DDI and allied experimental areas of small molecule drug metabolism as e.g. incubation of test substances using hepatocytes, human liver microsomes, recombinant enzymes.
- Analyzing incubation samples via LC-MS/MS and radio-HPLC, including the method development and/or validation.
- Plan, monitor, communicate and report enzymology/DDI studies both in a drug discovery and in drug development setting reporting to the respective laboratory staff and supervisors.
- Perform rigorous verification and develop best practices to improve the regular enzymology/DDI assays where current approaches are inadequate.
- Some time may be spent on supporting to develop new enzyme phenotyping methodologies and approaches.
- PhD or Post Doc in chemistry, biochemistry, pharmacokinetics or equivalent discipline with an interest in drug metabolism, pharmacokinetics (DMPK) and pharmacodynamics (PD)
- Min 3/5 years of experience in similar position in industry
- Experience in bioanalysis & in vitro assays
- Excellent knowledge of metabolic enzyme biochemistry (e.g. CYP, UGT), kinetics assessment and the respective experimental designs.
- You have a strong interest in translational approaches leveraging in vitro data and clinical data.
- Competence in method development/validation for radio-HPLC (e.g. Thermo) and LC-MS/MS (e.g. Sciex). This includes troubleshooting and data analysis (e.g. Analyst).
Place of work: Basel
Duration: 1 year
Please apply online. For further information about the position, please contact: Mrs Diana Steinhauer (+41 61 270 80 16).