Scientist Immunology

Posted 06 January 2022
SalaryNegotiable
LocationBasel
Job type Limited
DisciplineScienceLife Sciences
ReferenceBBBH505177_1641456253

Job description

For our client, a big pharmaceutical company with headquarters in Basel, we are looking for a

Scientist in Immunology

Background:

The Immunology Incubator is an innovative interface between Roche Pharma Research and Early Development (pRED) and the next generation of academic leaders. High potential, early to mid-career investigators and postdocs with an immunology background are embedded within pRED to conduct exploratory research that advances disease understanding and uncovers novel therapeutic targets.

This role sits within pRED in Immunology Discovery, part of the Immunology, Infections Diseases and Ophthalmology (I2O) Department, located in Basel, Switzerland. We are seeking an independent and highly motivated researcher to advance our understanding of the mechanisms underlying the progression of inflammatory bowel diseases (IBD). Specifically, the research project will aim at investigating the role of T cell plasticity in maintaining intestinal homeostasis and in the development of chronic and tissue-damaging intestinal inflammation. In addition the relationship between T cell plasticity and intestinal microbiota will be a central element of this project.

Ideal candidate:

To cover for a maternity leave, we are looking for a scientist with education in immunology (PhD are preferred, Master or Post Doc are considered). This person needs to have experience in human immunology, cell biology and flow cytometry. Please note experience in human immunology is a must.

Tasks & Responsibilities

  • Develop methods for isolation of immune cells from blood and tissue
  • Perform detailed immune phenotyping of cell populations of interest using multicolormulti-color flow cytometry
  • Perform sophisticated in vitro 3D cultures, including organoids, of human and mouse cells
  • Investigate the impact of bacterial isolates and/or metabolites on host immune, epithelial and stromal cells
  • In collaboration with data scientists, analyze multi omics data sets including scRNAseq, TCRseq, 16Sseq, metabolomics and identify molecules to be tested in vitro
  • Carry out in vivo studies to further mechanistic understanding
  • Form close collaborative relationships with other scientists within the Immunology Incubator, I2O Department and technical teams in other functions

Must Haves:

  • Min Master, preference on PhD in immunology
  • Profound understanding of human immunology, mucosal immunity and T cell biology
  • Extensive experience with state-of-the-art flow cytometry, including FACS
  • Track record of hands-on experience with isolation and cultivation of human immune cells
  • Experience with in vivo models of inflammation is a plus
  • Experience in data analysis using R or Python is a plus
  • You have very good interpersonal and communication skills, are able to build good working relationships and are an outstanding teammate
  • Your experience and investigative attitude allow you to work independently, to design, perform and interpret experiments and to embark on new scientific methodologies
  • You published as a leading author in top-tier journals
  • You have a strong team spirit, and you like to work in international teams
  • Your excellent English skills, written and spoken, complete your profile

General Information:

Start date: ASAP

Latest possible start date: 1 month notice period max

End date: 9 months duration

Extension: possible

Workplace: Basel

Workload: 100%

Remote/Home Office: Onsite needed, certificate will be required. Mostly onsite.

Your Application

Please apply online. For further information about the position, please contact your Kelly recruiter, Judith Atgé Martin (+41 61 270 80 16).